Cancer-derived small extracellular vesicles (sEVs) carry various messages and signal biomolecules to constitute key features of their parent cells, which make them as highly competitive non-invasive biomarkers for cancer diagnosis/prognosis. Additionally, new insights on the biogenesis and molecular functions of cancer-derived sEVs pave the way for novel sEV-based therapeutic strategies as drug carriers and/or for immunotherapy.[1] In this contribution, I will discuss our recent work on discovery of new biomarkers of sEVs via multi-omics approach, and the development of nanosensors for highly sensitive detection of sEVs using nanomaterial, surface-enhanced Raman scattering (SERS) and nanobiotechnology.[2-5] I will also discuss one example that how sEV can be hybridized with liposome for targeted cancer treatment [6].
[1] Zhang W, Campbell DH, Walsh B, Packer N, Liu D, Wang Y, J. Nanobiotech, 2022, 20, 446
[2] Zhang W, Wang L, Li D, Campbell DH, Walsh B, Packer N, Dong Q, Wang E, and Wang Y, Anal Method, 2022, 14, 2255
[3] Zhang W, Jiang L, Diefenbach RJ, Campbell DH, Walsh B, Packer N, Wang Y, ACS Sensors, 2020
[4] Fen X, Zhang W, Tsao S, Hu L, Wang Y, Nano Letter, 2025. DOI: acs.nanolett.5c04034
[5] Wang J, Wuethrich A, Sina AA, Lane R, Lin LL, Wang Y, Cebon J, Behren A, Trau M, Sci Adv, 2020, 6, ex3233.
[6] Zhang W, Ngo L, Tsao S, Liu D and Wang Y, ACS App Mat Int. 2023, 15, 16420.