Extracellular vesicles (EVs) play a critical role in intercellular communication and are emerging as biomarkers for disease diagnostics and therapeutic delivery. Similarly, viral vectors are widely used in gene therapy, vaccine development, and biotechnology applications. However, the purification of EVs and viruses remains a major challenge due to the presence of contaminants such as proteins, cellular debris, and unwanted nucleic acids.
Traditional methods like UC and TFF often yield impure samples with high levels of protein contamination. The EXODUS system overcomes these limitations by offering a rapid and scalable method to isolate exosomes and viruses with high purity and yield. EXODUS method enhances the recovery of exosomes and maintains structural integrity compared to UC and provides not only greater yield but also cleaner preparations offering a more efficient technique for isolating exosome-enriched extracellular vesicles. Once isolated the new NanoSight Pro NTA instrument with a specialised fluorescence mode achieves rapid characterisation to validate and identify EVs and their subpopulations, which is crucial for advancing EV research.